Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22261529 | 0.84 | HTT (0.49) | DHODHHTTGPR35KDM4EHPGD | |
| SCHEMBL5924825 | 0.79 | TDP1 (0.46) | DHODHHTTGPR35KDM4EHPGD | |
| SCHEMBL27785956 | 0.79 | MYC (0.50) | KDM4EHPGDALDH1A1HSD17B10TDP1 | |
| SCHEMBL15517040 | 0.78 | GPR35 (0.57) | DHODHHTTGPR35KDM4EHPGD | |
| SCHEMBL19320865 | 0.78 | MAPK1 (0.40) | DHODHKDM4ETDP1L3MBTL1KMT2A | |
| SCHEMBL14397485 | 0.78 | PRNP (0.46) | KDM4EHPGDALDH1A1HSD17B10TDP1 | |
| SCHEMBL7131872 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1 | |
| SCHEMBL7075388 | 0.77 | ALDH1A1 (0.48) | KDM4EHPGDALDH1A1HSD17B10TDP1 | |
| SCHEMBL27943872 | 0.76 | APP (0.50) | KDM4EALDH1A1HSD17B10TDP1L3MBTL1 | |
| SCHEMBL536179 | 0.76 | HTT (0.62) | HTTGPR35KDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051368-A1 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-26 | — | — | WO | disclosed |