Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.48 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | F9 | P00740 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18302280 | 0.82 | EPHX2 (0.56) | EPHX2AKT1KITKDRBRD4 | |
| SCHEMBL7072970 | 0.76 | MAP4K4 (0.46) | MAPK14KITKDRFLT3F9 | |
| SCHEMBL13525173 | 0.73 | MAPK14 (0.45) | MAPK14KITKDRFLT3F9 | |
| SCHEMBL2634187 | 0.72 | EPHX2 (0.58) | EPHX2AKT1KITKDRBRD4 | |
| SCHEMBL30410154 | 0.72 | EPHX2 (0.58) | EPHX2AKT1KITKDRBRD4 | |
| SCHEMBL14072365 | 0.71 | MAP4K4 (0.52) | S1PR1S1PR3MAPK14F9 | |
| SCHEMBL13376464 | 0.71 | MAP4K4 (0.58) | MAPK14KITKDRFLT3F9 | |
| SCHEMBL8003997 | 0.71 | MAPK14 (0.40) | EPHX2MAPK14BRD4F9 | |
| SCHEMBL21596796 | 0.70 | MAPK14 (0.42) | EPHX2MAPK14KITKDRFLT3 | |
| SCHEMBL14072810 | 0.70 | MAPK14 (0.42) | MAPK14BRD4F9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135023-A4 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | LILLY CO ELI (US) | 2003-03-05 | — | — | EP | disclosed |
| EP-1135023-A1 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | ELI LILLY AND COMPANY (US) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000027199-A1 | AMINOBENZISOXAZOLE COMPOUNDS AND LIBRARIES THEREOF | ELI LILLY AND COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000027627-A1 | ARYLOXIME LINKERS IN THE SOLID-PHASE SYNTHESIS OF 3-AMINOBENZISOXAZOLES | ELI LILLY AND COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |