SCHEMBL707209

SCHEMBL707209

NC(=O)Nn1cnc2ccccc21

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.58
HSD17B10 Q99714 1/20 0.58
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C19 P33261 1/20 0.53
CA12 O43570 3/20 0.51
CA1 P00915 3/20 0.51
CA2 P00918 3/20 0.51
CA7 P43166 3/20 0.51
CA9 Q16790 3/20 0.51
CA13 Q8N1Q1 3/20 0.51
CA3 P07451 2/20 0.51
CA4 P22748 2/20 0.51
CA6 P23280 2/20 0.51
CA5A P35218 2/20 0.51
CA14 Q9ULX7 2/20 0.51
CA5B Q9Y2D0 2/20 0.51
KDM4E B2RXH2 1/20 0.49
NPC1 O15118 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL204727 0.84 ALOX15 (0.64) ALOX15HSD17B10CYP1A2CYP3A4CYP2D6
SCHEMBL11025532 0.83 ALOX15 (0.51) ALOX15HSD17B10CYP1A2CYP3A4CYP2D6
SCHEMBL6954737 0.83 ALOX15 (0.58) ALOX15HSD17B10CYP1A2CYP3A4CYP2D6
SCHEMBL4447451 0.83 ALOX15 (0.51) ALOX15HSD17B10CYP1A2CYP3A4CYP2D6
SCHEMBL1685055 0.81 HSD17B10 (0.61) ALOX15HSD17B10CYP1A2CYP3A4CYP2D6
SCHEMBL5032715 0.79 FGFR1 (0.43) ALOX15HSD17B10CYP1A2CYP3A4CYP2D6
SCHEMBL18991593 0.79 HSD17B10 (0.66) ALOX15HSD17B10CYP1A2CYP3A4CYP2D6
SCHEMBL11844044 0.79 ALOX15 (0.55) ALOX15HSD17B10CYP1A2CYP3A4CYP2D6
SCHEMBL10318989 0.78 CYP2D6 (0.40) ALOX15HSD17B10CYP1A2CYP3A4CYP2D6
SCHEMBL11845978 0.78 ALOX15 (0.53) ALOX15HSD17B10CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024128568-A1 BENZIMIDAZOLYLUREA DERIVATIVE AND PHARMACEUTICAL USE THEREOF 경북대학교 산학협력단 2024-06-20 WO claimed
US-20130317222-A1 SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-(1-HYDROXY-1-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL]-1H-BENZIMIDAZOL-2-YL]UREA VERTEX PHARMACEUTICALS INCORPORATED 2013-11-28 US claimed
EP-2663558-A1 SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-{1-HYDROXY-1-METHYL-ETHYL}PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL}-1H-BENZIMIDAZOL-2-YL]UREA Vertex Pharmaceuticals Incorporated (US) 2013-11-20 EP claimed
US-8481552-B2 Solid forms of gyrase inhibitor (R)-1-ethyl-3-[5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-YL]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-YL]urea VERTEX PHARMACEUTICALS INCORPORATED (US) 2013-07-09 US claimed
US-20120184741-A1 SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-(1-HYDROXY-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA VERTEX PHARMACEUTICALS INCORPORATED (US) 2012-07-19 US claimed
WO-2012097270-A1 SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-{1-HYDROXY-1-METHYL-ETHYL}PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL}-1H-BENZIMIDAZOL-2-YL]UREA VERTEX PHARMACEUTICALS INCORPORATED (US) 2012-07-19 WO claimed
US-8124359-B2 Use of additives for the reduction of non-specific binding in assays AOKIN AG (DE) 2012-02-28 US claimed
US-7993855-B2 Use of additives to lower the rate of a binding reaction AOKIN AG (DE) 2011-08-09 US claimed
US-20090317922-A1 USE OF ADDITIVES TO LOWER THE RATE OF A BINDING REACTION AOKIN AG (DE) 2009-12-24 US claimed
US-20090311724-A1 USE OF ADDITIVES FOR THE REDUCTION OF NON-SPECIFIC BINDING IN ASSAYS AOKIN AG (DE) 2009-12-17 US claimed
EP-2005170-A1 USE OF ADDITIVES TO LOWER THE RATE OF A BINDING REACTION AOKIN AG (DE) 2008-12-24 EP claimed
EP-2005169-A2 USE OF ADDITIVES FOR THE REDUCTION OF NON-SPECIFIC BINDING IN ASSAYS AOKIN AG (DE) 2008-12-24 EP claimed
WO-2007111851-A1 USE OF ADDITIVES TO LOWER THE RATE OF A BINDING REACTION AOKIN AG (DE) 2007-10-04 WO claimed
WO-2007111847-A2 USE OF ADDITIVES FOR THE REDUCTION OF NON-SPECIFIC BINDING IN ASSAYS AOKIN AG (DE) 2007-10-04 WO claimed
CN-120513231-A Benzimidazolyl urea derivatives and pharmaceutical use thereof 庆北大学校产学协力团 2025-08-19 CN disclosed
WO-2024128568-A1 BENZIMIDAZOLYLUREA DERIVATIVE AND PHARMACEUTICAL USE THEREOF 경북대학교 산학협력단 2024-06-20 WO disclosed
US-11766419-B2 Mebeverine as soluble epoxide hydrolase inhibitor BANASTHALI VIDYAPITH (IN) 2023-09-26 US disclosed
US-4088768-A BENZIMIDAZOLYL, BENZOTHIAZOLYL, AND BENZOXAZOLYL UREAS AND THIOUREAS ELI LILLY AND COMPANY (US) 1978-05-09 US disclosed
US-4053598-A FUNGICIDES BAYER AKTIENGESELLSCHAFT (DT) 1977-10-11 US disclosed
US-3951920-A Permselective polymeric membrane prepared from polybenzimidazoles TEIJIN LIMITED (JA) 1976-04-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130317222-A1 SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-(1-HYDROXY-1-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL]-1H-BENZIMIDAZOL-2-YL]UREA TOP1, TOP2A, TOP2B ALOX15 4530/4885HSD17B10 1953/4885CYP1A2 516/4885
US-11766419-B2 Mebeverine as soluble epoxide hydrolase inhibitor EPHX1, EPHX2, NCEH1 ALOX15 312/4885HSD17B10 104/4885CYP1A2 71/4885
US-20120184741-A1 SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-(1-HYDROXY-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA TOP1, TOP2A, TOP2B ALOX15 4594/4885HSD17B10 2134/4885CYP1A2 664/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.