Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5732741 | 0.84 | PDE4A (0.47) | IDO1GSK3BMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL5354658 | 0.84 | PDE4A (0.50) | IDO1GSK3BMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL5736067 | 0.83 | PDE4A (0.49) | IDO1GSK3BMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL5275526 | 0.82 | MAPT (0.51) | IDO1GSK3BMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL6951615 | 0.78 | IDO1 (0.41) | IDO1GSK3BMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL6952027 | 0.78 | POLB (0.50) | IDO1GSK3BMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL31735796 | 0.77 | MAPT (0.47) | IDO1GSK3BMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL7694802 | 0.76 | MAPT (0.43) | IDO1GSK3BMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL16111315 | 0.76 | IDO1 (0.44) | IDO1MAPTL3MBTL1ALDH1A1TDO2 | |
| SCHEMBL9899738 | 0.76 | IDO1 (0.53) | IDO1GSK3BMAPTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363624-A2 | FLUORO OXINDOLE DERIVATIVES AS MODULATORS OF KCNQ POTASSIUM CHANNELS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-11-26 | — | — | EP | disclosed |
| US-20020156120-A1 | Fluoro oxindole derivatives as modulators of KCNQ potassium channels | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-24 | — | — | US | disclosed |
| US-6469042-B1 | ANALGESICS FOR MIGRAINES | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-22 | — | — | US | disclosed |
| WO-2002066426-A2 | FLUORO OXINDOLE DERIVATIVES AS MODULATORS OF KCNQ POTASSIUM CHANNELS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156120-A1 | Fluoro oxindole derivatives as modulators of KCNQ potassium channels | KCNQ1, KCNQ2, KCNQ3 | IDO1 1653/4885GSK3B 3702/4885MAPT 4514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.