Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 4/20 | 0.44 |
| ▸ | TDO2 | P48775 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5275526 | 0.88 | MAPT (0.51) | ALDH1A1MAPTL3MBTL1IDO1TDO2 | |
| SCHEMBL21282101 | 0.85 | POLB (0.47) | POLBALDH1A1MAPTL3MBTL1MEN1 | |
| SCHEMBL5879564 | 0.81 | POLB (0.49) | POLBALDH1A1MAPTL3MBTL1MEN1 | |
| SCHEMBL16111315 | 0.81 | IDO1 (0.44) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL6948710 | 0.80 | MAPT (0.42) | ALDH1A1MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL7072166 | 0.78 | IDO1 (0.49) | ALDH1A1MAPTL3MBTL1IDO1TDO2 | |
| SCHEMBL7694802 | 0.78 | MAPT (0.43) | ALDH1A1MAPTL3MBTL1IDO1TDO2 | |
| SCHEMBL18601130 | 0.76 | POLB (0.42) | POLBALDH1A1MAPTL3MBTL1MEN1 | |
| SCHEMBL31181916 | 0.76 | ALDH1A1 (0.42) | ALDH1A1MAPTL3MBTL1IDO1TDO2 | |
| SCHEMBL6297845 | 0.74 | MAPT (0.59) | POLBALDH1A1MAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116794202-A | Screening and application of metabolic markers of rifampicin drug-resistant tuberculosis | 首都医科大学附属北京胸科医院 | 2023-09-22 | — | — | CN | claimed |
| CN-115724785-A | Method for asymmetric catalytic synthesis of 3,3-disubstituted chiral indolone derivative | 重庆医科大学 | 2023-03-03 | — | — | CN | claimed |
| EP-1358180-A2 | NAPHTHOSTYRIL DERIVATIVES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | F. Hoffmann-La Roche AG (CH) | 2003-11-05 | — | — | EP | claimed |
| WO-2002059109-A2 | NAPHTHOSTYRIL DERIVATIVES AND THEIR USE AS INHIBITORS OF CYCLIN- DEPENDENT KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | claimed |
| CN-115894331-B | Method for asymmetric catalytic synthesis of 3, 3-disubstituted oxindole compounds | 重庆医科大学 | 2024-08-23 | — | — | CN | disclosed |
| CN-115894331-A | Method for asymmetric catalytic synthesis of 3, 3-disubstituted oxindole compounds | 重庆医科大学 | 2023-04-04 | — | — | CN | disclosed |
| CN-115724785-A | Method for asymmetric catalytic synthesis of 3,3-disubstituted chiral indolone derivative | 重庆医科大学 | 2023-03-03 | — | — | CN | disclosed |
| CN-115724785-A | Method for asymmetric catalytic synthesis of 3,3-disubstituted chiral indolone derivative | 重庆医科大学 | 2023-03-03 | — | — | CN | disclosed |