Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL166090 | 0.90 | ALDH1A1 (0.39) | ALDH1A1MAPTHPGDRECQL | |
| SCHEMBL23394794 | 0.85 | NPSR1 (0.50) | ALDH1A1EGLN1MAPTCYP2D6SMN1; SMN2 | |
| SCHEMBL7173968 | 0.82 | MAPT (0.32) | ALDH1A1TET2EGLN1MAPTHPGD | |
| SCHEMBL7172761 | 0.82 | MAPT (0.32) | ALDH1A1TET2EGLN1MAPTHPGD | |
| SCHEMBL26672101 | 0.82 | MAPT (0.32) | ALDH1A1TGFBR1TET2EGLN1MAPT | |
| SCHEMBL7171266 | 0.82 | MAPT (0.32) | ALDH1A1TET2EGLN1MAPTHPGD | |
| SCHEMBL11655452 | 0.79 | CES2 (0.42) | ALDH1A1MAPT | |
| SCHEMBL11655455 | 0.79 | CES2 (0.42) | ALDH1A1MAPT | |
| SCHEMBL166921 | 0.78 | ALDH1A1 (0.40) | ALDH1A1MAPTHPGDRECQL | |
| SCHEMBL6154107 | 0.78 | ALDH1A1 (0.40) | ALDH1A1MAPTHPGDRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0895776-B1 | Cosmetic light-screening composition | HOFFMANN LA ROCHE (CH) | 2003-06-11 | — | — | EP | disclosed |
| EP-0895776-A2 | Cosmetic light-screening composition | F. HOFFMANN-LA ROCHE AG (CH) | 1999-02-10 | — | — | EP | disclosed |