Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | F12 | P00748 | 3/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6481176 | 0.94 | PARP1 (0.45) | PARP1TNKS2PARP2F12CDK4 | |
| SCHEMBL6475935 | 0.90 | PARP1 (0.43) | PARP1TNKS2PARP2F12PDK4 | |
| SCHEMBL7075962 | 0.84 | CDK4 (0.47) | PARP1TNKS2PARP2F12CDK4 | |
| SCHEMBL6482451 | 0.80 | PARP1 (0.44) | PARP1TNKS2PARP2F12CDK4 | |
| SCHEMBL21630707 | 0.78 | CFTR (0.56) | PARP1TNKS2PARP2F12CFTR | |
| SCHEMBL6474214 | 0.75 | LMNA (0.60) | CDK4CCND1LMNAMAPTBAZ2B | |
| SCHEMBL6481710 | 0.74 | TRPV1 (0.45) | CDK4CCND1CFTRLMNAMAPT | |
| SCHEMBL25425099 | 0.74 | PRMT5 (0.43) | CDK9 | |
| SCHEMBL6475020 | 0.73 | F12 (0.43) | PARP1TNKS2PARP2F12PDK4 | |
| SCHEMBL21114784 | 0.73 | CTSK (0.48) | PARP1TNKS2PARP2F12PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1319004-A2 | SUBSTITUTED AZEPINO[4,5-B]INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024701-A2 | SUBSTITUTED AZEPINO[4,5B)INDOLE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2002-03-28 | — | — | WO | disclosed |