Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.47 |
| ▸ | CCND1 | P24385 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | F12 | P00748 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480610 | 0.87 | CDK4 (0.58) | CDK4CCND1LMNAMAPTGAA | |
| SCHEMBL7072797 | 0.84 | PARP1 (0.41) | CDK4CCND1LMNAMAPTF12 | |
| SCHEMBL6475935 | 0.84 | PARP1 (0.43) | LMNAMAPTF12PARP1TNKS2 | |
| SCHEMBL6473473 | 0.81 | LMNA (0.44) | CDK4CCND1LMNAMAPTTRPV1 | |
| SCHEMBL6481176 | 0.78 | PARP1 (0.45) | CDK4CCND1LMNAMAPTF12 | |
| SCHEMBL6474485 | 0.78 | CDK4 (0.45) | CDK4CCND1LMNAMAPTKMT2A | |
| SCHEMBL6481844 | 0.78 | MGLL (0.45) | CDK4CCND1 | |
| SCHEMBL25425099 | 0.75 | PRMT5 (0.43) | MEN1KMT2A | |
| SCHEMBL6474154 | 0.75 | PDE4B (0.46) | CDK4CCND1LMNAMAPTPOLB | |
| SCHEMBL6474174 | 0.74 | CDK4 (0.45) | CDK4CCND1LMNAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1319005-A2 | SUBSTITUTED AZEPINO[4,5-B]INDOLINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024700-A2 | SUBSTITUTED AZEPINO[4,5b]INDOLINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2002-03-28 | — | — | WO | disclosed |