Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 13/20 | 0.56 |
| ▸ | THRA | P10827 | 10/20 | 0.56 |
| ▸ | RORC | P51449 | 4/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5283822 | 0.83 | THRB (0.57) | THRBTHRARORC | |
| SCHEMBL5041163 | 0.83 | THRB (0.52) | THRBTHRARORC | |
| SCHEMBL8893247 | 0.82 | THRB (0.57) | THRBTHRARORCCYP2D6 | |
| SCHEMBL8892589 | 0.81 | THRB (0.53) | THRBTHRARORCCYP2D6 | |
| SCHEMBL3886566 | 0.80 | THRB (0.57) | THRBTHRARORC | |
| SCHEMBL16496567 | 0.77 | THRB (0.53) | THRBTHRARORC | |
| SCHEMBL7071121 | 0.77 | THRB (0.55) | THRBTHRARORC | |
| SCHEMBL7076989 | 0.77 | THRB (0.73) | THRBTHRARORC | |
| SCHEMBL5618523 | 0.77 | THRB (0.53) | THRBTHRARORCCYP2D6 | |
| SCHEMBL8064329 | 0.77 | THRB (0.49) | THRBTHRARORCCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000008-B1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KAROBIO AB (SE) | 2003-06-25 | — | — | EP | disclosed |
| US-6465687-B1 | SUBSTITUTED 4-HYDROXY-3-ALKYL- OR CYCLOALKYL-PHENOXYBENZENE COMPOUNDS SUCH AS 3,5-DIBROMO-4-(4-HYDROXY-3-ISOPROPYLPHENOXY)BENZOIC ACID, EXPRESSION INHIBITION OF A T3 REGULATED GENE | KARO BIO AB (SE) | 2002-10-15 | — | — | US | disclosed |