Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 16/20 | 0.55 |
| ▸ | RORC | P51449 | 3/20 | 0.55 |
| ▸ | THRA | P10827 | 13/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3886566 | 0.89 | THRB (0.57) | THRBRORCTHRA | |
| SCHEMBL7076989 | 0.87 | THRB (0.73) | THRBRORCTHRA | |
| SCHEMBL7069261 | 0.84 | THRB (0.77) | THRBRORCTHRA | |
| SCHEMBL8893247 | 0.83 | THRB (0.57) | THRBRORCTHRA | |
| SCHEMBL7069926 | 0.83 | THRA (0.71) | THRBTHRA | |
| SCHEMBL5276573 | 0.83 | THRB (0.74) | THRBRORCTHRA | |
| SCHEMBL8892589 | 0.82 | THRB (0.53) | THRBRORCTHRA | |
| SCHEMBL3160730 | 0.82 | THRB (0.75) | THRBRORCTHRA | |
| SCHEMBL5618343 | 0.82 | THRB (0.60) | THRBRORCTHRA | |
| SCHEMBL4212085 | 0.82 | THRB (0.58) | THRBRORCTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000008-B1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KAROBIO AB (SE) | 2003-06-25 | — | — | EP | disclosed |
| US-6465687-B1 | SUBSTITUTED 4-HYDROXY-3-ALKYL- OR CYCLOALKYL-PHENOXYBENZENE COMPOUNDS SUCH AS 3,5-DIBROMO-4-(4-HYDROXY-3-ISOPROPYLPHENOXY)BENZOIC ACID, EXPRESSION INHIBITION OF A T3 REGULATED GENE | KARO BIO AB (SE) | 2002-10-15 | — | — | US | disclosed |
| EP-1000008-A1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KARO BIO AB (SE) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999000353-A1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KARO BIO AB (SE) | 1999-01-07 | — | — | WO | disclosed |