Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.54 |
| ▸ | DRD3 | P35462 | 9/20 | 0.54 |
| ▸ | DRD4 | P21917 | 4/20 | 0.54 |
| ▸ | HTR1D | P28221 | 3/20 | 0.54 |
| ▸ | HTR1B | P28222 | 3/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7073836 | 1.00 | DRD2 (0.54) | DRD2DRD3DRD4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL8686894 | 0.99 | DRD2 (0.53) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7199976 | 0.78 | MTNR1A (0.56) | — | |
| SCHEMBL8462877 | 0.77 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL7356162 | 0.76 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL7356167 | 0.76 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL6932016 | 0.75 | MTNR1A (0.38) | DRD2DRD3DRD4 | |
| SCHEMBL21798817 | 0.74 | DRD2 (0.68) | DRD2DRD3DRD4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL7337535 | 0.73 | DRD2 (0.67) | DRD2DRD3DRD4HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL7337532 | 0.73 | DRD2 (0.67) | DRD2DRD3DRD4HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768307-B1 | Heterocyclic tertiary amines, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-26 | — | — | EP | disclosed |
| EP-0768307-B1 | Heterocyclic tertiary amines, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-26 | — | — | EP | disclosed |
| EP-0768307-A1 | Heterocyclic tertiary amines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1997-04-16 | — | — | EP | disclosed |