Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5730287 | 0.98 | BRPF1 (0.37) | BRPF1TRPA1ALOX15HSD17B10MEN1 | |
| SCHEMBL3795932 | 0.73 | CYP1A2 (0.34) | MEN1KMT2AGAA | |
| Bromide SCHEMBL7993026 | 0.68 | NOS2 (0.38) | GAAMAPT | |
| SCHEMBL38765 | 0.67 | BRPF1 (0.39) | BRPF1ALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL6137103 | 0.67 | MAPT (0.48) | BRPF1ALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL5947951 | 0.66 | — | — | |
| SCHEMBL34525 | 0.66 | NOS2 (0.39) | ALOX15HSD17B10GAAMAPT | |
| SCHEMBL30051018 | 0.66 | NOS2 (0.39) | ALOX15HSD17B10GAAMAPT | |
| SCHEMBL1384491 | 0.65 | GAA (0.32) | GAAMAPT | |
| SCHEMBL3541131 | 0.64 | NOS2 (0.38) | GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289966-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION | Bristol-Myers Squibb Pharma Company (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001077086-A1 | SUBSTITUTED LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DUPONT PHARMACEUTICALS COMPANY (US) | 2001-10-18 | — | — | WO | disclosed |