Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.50 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.50 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.44 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6808464 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2SLC1A2SLC1A1CA2 | |
| SCHEMBL27573982 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2SLC1A2SLC1A1CA2 | |
| SCHEMBL7066300 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2SLC1A2SLC1A1CA2 | |
| SCHEMBL6138155 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2SLC1A2SLC1A1CA2 | |
| SCHEMBL7069281 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2SLC1A2SLC1A1CA2 | |
| SCHEMBL7304504 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2SLC1A2SLC1A1CA2 | |
| SCHEMBL8217023 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2SLC1A2SLC1A1CA2 | |
| SCHEMBL8217020 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2SLC1A2SLC1A1CA2 | |
| SCHEMBL6808467 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2SLC1A2SLC1A1CA2 | |
| SCHEMBL7296146 | 1.00 | GRIK1 (0.50) | GRIK1GRIK2SLC1A2SLC1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030225272-A1 | Novel mmp-2/mmp-9 inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-12-04 | — | — | US | disclosed |
| WO-2001026671-A1 | METHODS OF TREATMENT USING DUAL MATRIX-METALLOPROTEINASE-2 AND MATRIX METALLOPROTEINASE-9 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-19 | — | — | WO | disclosed |
| EP-0575844-B1 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | HOFFMANN LA ROCHE (CH) | 1998-01-21 | — | — | EP | disclosed |
| EP-0575844-A2 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | F. HOFFMANN-LA ROCHE AG (CH) | 1993-12-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225272-A1 | Novel mmp-2/mmp-9 inhibitors | MMP9, MMP10, MMP3 | GRIK1 3829/4885GRIK2 2506/4885SLC1A2 3181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.