Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.52 |
| ▸ | PTGES | O14684 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TYMP | P19971 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16783535 | 0.81 | PTGES (0.50) | PTGESALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL31179761 | 0.81 | PTGES (0.50) | PTGESALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL14471296 | 0.78 | ALDH1A1 (0.55) | ALDH1A1KDM4ESMN1; SMN2LMNACYP1A2 | |
| SCHEMBL18672450 | 0.78 | PTGES (0.50) | PTGESALDH1A1KDM4EELANESMN1; SMN2 | |
| SCHEMBL6602571 | 0.74 | CYP2C9 (0.51) | PTGESALDH1A1KDM4EELANESMN1; SMN2 | |
| SCHEMBL1882695 | 0.74 | AKR1B1 (0.55) | AKR1B1ALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL175987 | 0.73 | ALDH1A1 (0.59) | PTGESALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL31179758 | 0.72 | ALDH1A1 (0.41) | PTGESALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL7689786 | 0.71 | ALDH1A1 (0.60) | PTGESALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL15641308 | 0.71 | AKR1B1 (0.53) | AKR1B1ALDH1A1KDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003105842-A1 | DERIVATIVES OF CHROMEN-2-ONE AS INHIBITORS OF VEGF PRODUCTION IN MAMMALIAN CELLS | NOVUSPHARMA S.P.A. (IT) | 2003-12-24 | — | — | WO | disclosed |