SCHEMBL175987

SCHEMBL175987

O=C(O)c1cc2ccccc2c(=O)o1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.59
HPGD P15428 8/20 0.59
HTT P42858 2/20 0.59
KDM4E B2RXH2 5/20 0.57
PTGES O14684 1/20 0.56
HSD17B10 Q99714 3/20 0.56
GLA P06280 3/20 0.56
TDP1 Q9NUW8 2/20 0.56
L3MBTL1 Q9Y468 2/20 0.56
MAPT P10636 1/20 0.56
TSHR P16473 1/20 0.56
LMNA P02545 3/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
CSNK2A1 P68400 3/20 0.54
CSNK2A2 P19784 2/20 0.54
CSNK2B P67870 2/20 0.54
CSNK2A3 Q8NEV1 2/20 0.54
USP2 O75604 1/20 0.54
PTGS1 P23219 1/20 0.54
CYP1A2 P05177 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Formic Acid SCHEMBL11853384 0.93 ALDH1A1 (0.55) ALDH1A1HPGDHTTKDM4EPTGES
SCHEMBL7689786 0.84 ALDH1A1 (0.60) ALDH1A1HPGDHTTKDM4EPTGES
SCHEMBL14402282 0.84 ALDH1A1 (0.57) ALDH1A1HPGDHTTKDM4EPTGES
SCHEMBL5554968 0.82 ALDH1A1 (0.56) ALDH1A1HPGDHTTKDM4EPTGES
SCHEMBL11839493 0.82 ALDH1A1 (0.56) ALDH1A1HPGDHTTKDM4EPTGES
SCHEMBL28923800 0.81 ALDH1A1 (0.65) ALDH1A1HPGDHTTKDM4EPTGES
SCHEMBL11853380 0.77 ALDH1A1 (0.52) ALDH1A1HPGDHTTKDM4EPTGES
SCHEMBL2895883 0.76 HPGD (0.64) ALDH1A1HPGDHTTKDM4EHSD17B10
SCHEMBL28805121 0.76 ALDH1A1 (0.59) ALDH1A1HPGDHTTKDM4EHSD17B10
SCHEMBL155789 0.75 FLT3 (0.74) ALDH1A1HPGDHTTKDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8968711-B2 Cosmetic or dermatological composition comprising a polymer bearing junction groups, and cosmetic treatment process L'OREAL (FR) 2015-03-03 US claimed
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT L'OREAL (FR) 2010-10-28 US claimed
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS L'OREAL (FR) 2010-09-23 US claimed
US-3987185-A INGIBITS ANTIGEN-ANTIBODY REACTIONS IN ANIMALS RICHARDSON-MERRELL INC. (US) 1976-10-19 US claimed
EP-2511266-B1 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES UNIV CALIFORNIA (US) 2019-09-04 EP disclosed
US-9556122-B2 Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-01-31 US disclosed
US-9556122-B2 Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-01-31 US disclosed
US-8968711-B2 Cosmetic or dermatological composition comprising a polymer bearing junction groups, and cosmetic treatment process L'OREAL (FR) 2015-03-03 US disclosed
US-20140039169-A1 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2014-02-06 US disclosed
US-20140039169-A1 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2014-02-06 US disclosed
US-8618129-B2 Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators GRUENENTHAL GMBH (DE) 2013-12-31 US disclosed
US-8557601-B2 Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-10-15 US disclosed
US-5700810-A Condensed heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-12-23 US disclosed
US-5482967-A LOWERING CHOLESTEROL TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-01-09 US disclosed
CN-1090274-A Condensed heterocyclic compounds and its preparation method and application TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1994-08-03 CN disclosed
EP-0585913-A2 Condensed heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-03-09 EP disclosed
US-4711956-A GRAMPOSITIVE, GRAMNEGATIVE BACTERIA TPO "PHARMACHIM" (BG) 1987-12-08 US disclosed
US-4036964-A Isocarbostyril-3-carboxylic acid derivatives for the prophylaxis of asthma, hayfever and rhinitis BEECHAM GROUP LIMITED (EN) 1977-07-19 US disclosed
US-3987185-A INGIBITS ANTIGEN-ANTIBODY REACTIONS IN ANIMALS RICHARDSON-MERRELL INC. (US) 1976-10-19 US disclosed
US-3975535-A Anti-allergic-3-carboxy-isocoumarin compositions and methods of use BEECHAM GROUP LIMITED (EN) 1976-08-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140039169-A1 LUMINESCENT 1-HYDROXY-2-PYRIDINONE CHELATES OF LANTHANIDES PLPBP, HPD, LASP1 ALDH1A1 411/4885HPGD 21/4885HTT 718/4885
US-20100239509-A1 COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A POLYMER BEARING JUNCTION GROUPS, AND COSMETIC TREATMENT PROCESS CUTA, SUCLG1, KRT18 ALDH1A1 1901/4885HPGD 311/4885HTT 2106/4885
US-20100272660-A1 COSMETIC OR PHARMACEUTICAL COMPOSITION COMPRISING A POLYCONDENSATE, THE SAID POLYCONDENSATE AND METHOD OF COSMETIC TREATMENT ACMSD, CUTA, PCCA ALDH1A1 1510/4885HPGD 826/4885HTT 488/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.