Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.47 |
| ▸ | LSS | P48449 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | BCL2 | P10415 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7075963 | 0.96 | ALDH1A1 (0.55) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7131687 | 0.94 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL1776033 | 0.89 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7076016 | 0.88 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7136554 | 0.85 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL14002943 | 0.83 | LSS (0.48) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7076583 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7131362 | 0.81 | KDM4E (0.54) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7078258 | 0.78 | DHODH (0.54) | KDM4EALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL7225276 | 0.78 | RXRA (0.67) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051368-A1 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-26 | — | — | WO | disclosed |