Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.46 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076016 | 0.94 | KDM4E (0.49) | KDM4EALDH1A1LMNACHRNB2CHRNA4 | |
| SCHEMBL7136554 | 0.93 | ALDH1A1 (0.50) | KDM4EALDH1A1LMNACHRNB2CHRNA4 | |
| SCHEMBL7131687 | 0.88 | KDM4E (0.53) | KDM4EALDH1A1LMNACHRNB2CHRNA4 | |
| SCHEMBL7130108 | 0.86 | KDM4E (0.43) | KDM4EALDH1A1LMNATDP1L3MBTL1 | |
| SCHEMBL7075715 | 0.86 | KDM4E (0.43) | KDM4EALDH1A1LMNATDP1L3MBTL1 | |
| SCHEMBL7074931 | 0.84 | KDM4E (0.44) | KDM4EALDH1A1LMNATDP1L3MBTL1 | |
| SCHEMBL7076243 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1LMNACHRNB2CHRNA4 | |
| SCHEMBL7075963 | 0.81 | ALDH1A1 (0.55) | KDM4EALDH1A1LMNAESR1SMN1; SMN2 | |
| SCHEMBL1776033 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1LMNACHRNB2CHRNA4 | |
| SCHEMBL7135585 | 0.79 | BACE1 (0.56) | KDM4EALDH1A1ESR1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051368-A1 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-26 | — | — | WO | disclosed |