Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708406 | 0.91 | KCNH2 (0.55) | KCNH2CHRM1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL708589 | 0.87 | KCNH2 (0.51) | KCNH2CHRM1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL709161 | 0.87 | KCNH2 (0.51) | KCNH2CHRM1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL705652 | 0.86 | TSHR (0.53) | CHRM1ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL707302 | 0.85 | KMO (0.56) | KCNH2CHRM1KMOUTS2R | |
| SCHEMBL707115 | 0.84 | KCNH2 (0.56) | KCNH2CHRM1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL704650 | 0.83 | CHRM1 (0.60) | KCNH2CHRM1ALDH1A1UTS2RCHRM5 | |
| SCHEMBL705187 | 0.83 | KCNH2 (0.53) | KCNH2CHRM1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL706189 | 0.83 | KCNH2 (0.54) | KCNH2CHRM1ALDH1A1 | |
| SCHEMBL922179 | 0.82 | KCNH2 (0.63) | KCNH2CHRM1CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124602-B2 | Compounds for the treatment of multi-drug resistant bacterial infections | ASTRAZENECA AB (SE) | 2012-02-28 | — | — | US | disclosed |
| US-20110092495-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2011-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092495-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | PIGS, BPGM, IPMK | KCNH2 4242/4885CHRM1 4854/4885ALDH1A1 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.