Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 19/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 18/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 16/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8452305 | 0.97 | SLC6A4 (0.58) | SLC6A4SLC6A3SLC6A2CYP2D6CYP1A1 | |
| SCHEMBL6957304 | 0.95 | SLC6A2 (0.50) | SLC6A4SLC6A3SLC6A2CYP2D6CYP1A1 | |
| SCHEMBL8290900 | 0.94 | SLC6A4 (0.55) | SLC6A4SLC6A3SLC6A2CYP2D6CYP1A1 | |
| SCHEMBL7751548 | 0.91 | SLC6A4 (0.56) | SLC6A4SLC6A3SLC6A2CYP2D6CYP1A1 | |
| SCHEMBL8291781 | 0.91 | SLC6A3 (0.46) | SLC6A4SLC6A3SLC6A2CYP2D6CYP1A1 | |
| SCHEMBL7947168 | 0.89 | SLC6A2 (0.48) | SLC6A4SLC6A3SLC6A2CYP2D6CYP1A1 | |
| SCHEMBL5200993 | 0.86 | SLC6A4 (0.39) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL7766689 | 0.84 | SLC6A3 (0.39) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL6950573 | 0.83 | TACR1 (0.39) | SLC6A4SLC6A3SLC6A2CYP2D6 | |
| SCHEMBL8970579 | 0.83 | SLC6A2 (0.41) | SLC6A4SLC6A3SLC6A2CYP2D6CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770735-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-23 | — | — | US | claimed |
| EP-0871623-B1 | 3-AZETIDINYLALKYLPIPERIDINES OR -PYRROLIDINES AS TACHYKININ ANTAGONISTS | PFIZER RES & DEV (IE) | 2003-02-12 | — | — | EP | disclosed |
| US-6242438-B1 | 3-Azetidinylalkylpiperidines or -pyrrolidines as tachykinin antagonists | PFIZER INC. | 2001-06-05 | — | — | US | disclosed |
| US-5965580-A | TREATMENT OF SUBSTANCE P- AND NEUROKININ-DEPENDENT DISORDERS | SANOFI (FR) | 1999-10-12 | — | — | US | disclosed |
| US-5939411-A | PIPERIDINE DERIVATIVES SUBSTITUTED AT POSITION 4 WITH NEW FUNCTIONS OTHER THAN THOSE DESCRIBED PREVIOUSLY HAVE A HIGH AFFINITY FOR NEUROKININ RECEPTORS AND ARE USEFUL FOR TREATMENT OF SUBSTANCE P AND NEUROKININ DEPENDENT PATHOLOGIES | SANOFI (FR) | 1999-08-17 | — | — | US | disclosed |
| EP-0512901-B1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-06-23 | — | — | EP | disclosed |
| EP-0591040-B1 | Quaternary basic amides as tachykinines antagonists | SANOFI SA (FR) | 1999-02-03 | — | — | EP | disclosed |
| US-5830906-A | Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them | SANOFI (FR) | 1998-11-03 | — | — | US | disclosed |
| US-5770735-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-23 | — | — | US | disclosed |
| US-5712288-A | TACHYKININ ANTAGONIST, ANTIINFLAMMATORY, ANTIALLERGEN | SANOFI (FR) | 1998-01-27 | — | — | US | disclosed |
| US-5665886-A | Salts of substituted nitrogenous heteroaromatic compounds, a process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1997-09-09 | — | — | US | disclosed |
| US-5625060-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present | Sanofi, Elf (FR) | 1997-04-29 | — | — | US | disclosed |
| US-5583134-A | QUATERNARY BASIC AMIDE DERIVATIVES; USEFUL FOR TREATING PATHOLOGICAL CONDITION INVOLVING THE TACHYKININ SYSTEM | SANOFI (FR) | 1996-12-10 | — | — | US | disclosed |
| US-5554763-A | TACHYKININ ANTAGONISTS | SANOFI (FR) | 1996-09-10 | — | — | US | disclosed |
| EP-0714891-A1 | Heterocyclic tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-06-05 | — | — | EP | disclosed |
| EP-0700387-A1 | SALTS OF SUBSTITUTED HETEROAROMATIC NITROGEN COMPOUNDS, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING SAME | SANOFI (FR) | 1996-03-13 | — | — | EP | disclosed |
| WO-1995026339-A1 | SALTS OF SUBSTITUTED HETEROAROMATIC NITROGEN COMPOUNDS, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING SAME | SANOFI (FR) | 1995-10-05 | — | — | WO | disclosed |
| US-5340822-A | Substance P, neurokinin antagonists | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |
| EP-0591040-A1 | Quaternary basic amides as tachykinines antagonists | SANOFI (FR) | 1994-04-06 | — | — | EP | disclosed |
| EP-0512901-A1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-11-11 | — | — | EP | disclosed |