Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.35 |
| ▸ | TYMS | P04818 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973994 | 0.89 | TYMS (0.31) | TYMS | |
| SCHEMBL7081642 | 0.88 | TP53 (0.39) | TP53RXFP1SLC6A9TYMSHPGD | |
| SCHEMBL6962736 | 0.87 | TYMS (0.35) | SLC6A9TYMSALDH1A1LMNA | |
| SCHEMBL6966250 | 0.86 | TUBB4A (0.37) | TP53HPGDMAPTMEN1GAA | |
| SCHEMBL6968877 | 0.86 | SLC6A9 (0.36) | TP53RXFP1SLC6A9TYMSHPGD | |
| SCHEMBL7081545 | 0.83 | CSNK2A2 (0.34) | TP53RXFP1SLC6A9TYMSKMT2A | |
| SCHEMBL6969750 | 0.83 | HSP90AA1 (0.38) | HPGDMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7086123 | 0.83 | TYMS (0.37) | TP53RXFP1TYMSHPGDMAPT | |
| SCHEMBL6964414 | 0.83 | HPGD (0.38) | TP53RXFP1SLC6A9TYMSHPGD | |
| SCHEMBL7078935 | 0.82 | SLC6A9 (0.34) | TP53RXFP1SLC6A9TYMSHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |