SCHEMBL6968877

SCHEMBL6968877

CC(=O)OCCOC(C)c1nc(C(C)C)c(Sc2cccc(Cl)c2)[nH]1

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 4/20 0.36
ALOX12 P18054 1/20 0.35
TP53 P04637 2/20 0.34
RXFP1 Q9HBX9 1/20 0.34
TYMS P04818 3/20 0.32
HPGD P15428 1/20 0.32
DHFR P00374 1/20 0.32
LMNA P02545 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MEN1 O00255 1/20 0.31
CYP1A2 P05177 1/20 0.31
MAPT P10636 1/20 0.31
CYP2C9 P11712 1/20 0.31
TSHR P16473 1/20 0.31
MAPK1 P28482 1/20 0.31
CYP2C19 P33261 1/20 0.31
HTT P42858 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6967488 0.90 TLR8 (0.30)
SCHEMBL7086458 0.90 TP53 (0.36) SLC6A9ALOX12TP53RXFP1TYMS
SCHEMBL7082473 0.89 SLC6A9 (0.34) SLC6A9TYMSLMNAALDH1A1MAPT
SCHEMBL6964916 0.88 TUBB4A (0.33) HPGDDHFRALDH1A1MEN1CYP1A2
SCHEMBL7078935 0.87 SLC6A9 (0.34) SLC6A9ALOX12TP53RXFP1TYMS
SCHEMBL7078166 0.86 TP53 (0.35) SLC6A9ALOX12TP53RXFP1TYMS
SCHEMBL7085474 0.85 CYP2C9 (0.38) LMNAALDH1A1MEN1CYP1A2MAPT
SCHEMBL6973004 0.85 SLC6A9 (0.32) SLC6A9ALOX12TP53RXFP1KMT2A
SCHEMBL6973420 0.84 SMN1; SMN2 (0.35) SLC6A9TP53RXFP1ALDH1A1MAPT
SCHEMBL7084647 0.83 ALDH1A1 (0.38) SLC6A9LMNAALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed