Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 4/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7070791 | 0.90 | ESR2 (0.38) | CA1CA2CA7CA9ESR1 | |
| SCHEMBL7074724 | 0.69 | KDM4E (0.30) | CA1CA2CA7CA9ESR1 | |
| SCHEMBL7078470 | 0.67 | OPRM1 (0.33) | — | |
| SCHEMBL7075018 | 0.66 | ESR1 (0.46) | ESR1ESR2 | |
| SCHEMBL19737863 | 0.66 | PBRM1 (0.47) | PBRM1CA1CA2CA7CA9 | |
| SCHEMBL6794708 | 0.64 | PBRM1 (0.46) | PBRM1CA1CA2CA7CA9 | |
| SCHEMBL7076088 | 0.64 | SHBG (0.33) | — | |
| SCHEMBL6794055 | 0.63 | ESR1 (0.44) | PBRM1CA1CA2CA7CA9 | |
| SCHEMBL7072886 | 0.62 | — | — | |
| SCHEMBL17355128 | 0.60 | ESR1 (0.42) | PBRM1CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339662-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS AND METHODS III | KARO BIO AB (SE) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002046134-A1 | NOVEL ESTROGEN RECEPTOR LIGANDS AND METHODS III | KARO BIO AB (SE) | 2002-06-13 | — | — | WO | disclosed |