Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | TLR4 | O00206 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1177125 | 0.75 | CRBN (0.43) | CRBNSMN1; SMN2KMT2AMAPTMAPK1 | |
| SCHEMBL8161915 | 0.73 | MAPT (0.48) | CRBNSMN1; SMN2MAPTTLR4 | |
| SCHEMBL1494349 | 0.73 | CRBN (0.42) | CRBNSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL17963605 | 0.73 | CA1 (0.33) | CRBNSMN1; SMN2CA1CA2CA4 | |
| SCHEMBL7029411 | 0.72 | — | — | |
| SCHEMBL661313 | 0.72 | — | — | |
| SCHEMBL1073565 | 0.72 | — | — | |
| SCHEMBL9803938 | 0.72 | — | — | |
| SCHEMBL12808170 | 0.70 | — | — | |
| SCHEMBL844526 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11465963-B2 | Tetrahydronaphthalene derivatives useful as Nrf2 activators | BIOGEN MA INC. (US) | 2022-10-11 | — | — | US | disclosed |
| US-20200299230-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES USEFUL AS NRF2 ACTIVATORS | BIOGEN MA INC. | 2020-09-24 | — | — | US | disclosed |
| US-20190270700-A1 | METHODS AND COMPOSITIONS FOR TERPENOID SYNTHESIS | UNIV FLORIDA (US) | 2019-09-05 | — | — | US | disclosed |
| EP-2540772-B1 | WEATHER-RESISTANT VINYL CHLORIDE RESIN COMPOSITION | ADEKA CORP (JP) | 2017-03-29 | — | — | EP | disclosed |
| EP-2540772-A1 | WEATHER-RESISTANT VINYL CHLORIDE RESIN COMPOSITION | Adeka Corporation (JP) | 2013-01-02 | — | — | EP | disclosed |
| US-7807703-B2 | Herbicides; pesticides | BAYER CROPSCIENCE AG (DE) | 2010-10-05 | — | — | US | disclosed |
| US-7807703-B2 | Herbicides; pesticides | BAYER CROPSCIENCE AG (DE) | 2010-10-05 | — | — | US | disclosed |
| US-20100035756-A1 | TRIAZOLOPHYRIDINE DERIVATIVES AS HERBICIDES | SYNGENTA LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| US-20100035756-A1 | TRIAZOLOPHYRIDINE DERIVATIVES AS HERBICIDES | SYNGENTA LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| WO-2008006540-A1 | TRIAZOLOPYRIDINE DERIVATIVES AS HERBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2008-01-17 | — | — | WO | disclosed |
| US-20030149293-A1 | Method for producing 1,3-cyclohexanediol compound | MITSUBISHI CHEMICAL CORPORATION (JP) | 2003-08-07 | — | — | US | disclosed |
| EP-1333019-A1 | Method for producing 1,3-cyclohexanediol compound | MITSUBISHI CHEMICAL CORPORATION (JP) | 2003-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149293-A1 | Method for producing 1,3-cyclohexanediol compound | NISCH, HSD11B2, ACMSD | CRBN 2919/4885SMN1; SMN2 3288/4885CA1 63/4885 |
| US-20100035756-A1 | TRIAZOLOPHYRIDINE DERIVATIVES AS HERBICIDES | DDT, CYP1A1, NAT1 | CRBN 3876/4885SMN1; SMN2 4350/4885CA1 2889/4885 |
| US-20200299230-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES USEFUL AS NRF2 ACTIVATORS | NFE2L2, KEAP1, NQO1 | CRBN 1846/4885SMN1; SMN2 2719/4885CA1 4863/4885 |
| US-11465963-B2 | Tetrahydronaphthalene derivatives useful as Nrf2 activators | NFE2L2, KEAP1, NQO1 | CRBN 1846/4885SMN1; SMN2 2719/4885CA1 4863/4885 |
| US-20190270700-A1 | METHODS AND COMPOSITIONS FOR TERPENOID SYNTHESIS | SQLE, GGPS1, LSS | CRBN 1572/4885SMN1; SMN2 4694/4885CA1 4487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.