Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 6/20 | 0.47 |
| ▸ | CCR9 | P51686 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 6/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3964056 | 0.83 | F10 (0.47) | — | |
| SCHEMBL6300529 | 0.80 | CCR2 (0.49) | CCR2CCR9RHEBTP53MAPT | |
| SCHEMBL6303493 | 0.78 | CCR2 (0.62) | CCR2CCR9RHEBMAPT | |
| SCHEMBL701444 | 0.77 | GPR35 (0.46) | CCR2CCR9RHEBTP53MAPT | |
| SCHEMBL4209306 | 0.76 | CCR9 (0.56) | CCR2CCR9RHEB | |
| SCHEMBL6300706 | 0.75 | CCR9 (0.53) | CCR2CCR9RHEB | |
| SCHEMBL7076151 | 0.72 | CCR2 (0.66) | CCR2 | |
| SCHEMBL6300781 | 0.72 | CCR2 (0.53) | CCR2CCR9RHEB | |
| SCHEMBL6221773 | 0.70 | HSD17B10 (0.54) | RHEB | |
| SCHEMBL3962467 | 0.70 | F10 (0.55) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | disclosed |
| US-6441004-B1 | INDOLE DERIVATIVES AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 2002-08-27 | — | — | US | disclosed |