Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 4/20 | 0.54 |
| ▸ | CCR2 | P41597 | 16/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072404 | 0.89 | CCR2 (0.67) | ABCB11CCR2 | |
| SCHEMBL7076054 | 0.87 | ABCB11 (0.67) | ABCB11CCR2 | |
| SCHEMBL7076520 | 0.87 | CCR2 (0.53) | ABCB11CCR2 | |
| SCHEMBL9239991 | 0.84 | CCR2 (0.67) | ABCB11CCR2LMNAGAAMAPT | |
| SCHEMBL7076795 | 0.83 | CCR2 (0.71) | ABCB11CCR2 | |
| SCHEMBL7071931 | 0.82 | CCR2 (0.72) | ABCB11CCR2HTTSMN1; SMN2 | |
| SCHEMBL6303108 | 0.82 | CCR2 (0.79) | ABCB11CCR2 | |
| SCHEMBL5682947 | 0.82 | CCR2 (0.57) | ABCB11CCR2LMNAGAAMAPT | |
| SCHEMBL7074180 | 0.81 | CCR2 (0.68) | ABCB11CCR2 | |
| SCHEMBL7076337 | 0.79 | CCR2 (0.69) | ABCB11CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | claimed |