Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084572 | 0.90 | HMGCR (0.40) | HMGCRPOLBTHRBTHRAHSD11B1 | |
| SCHEMBL7083305 | 0.87 | GAA (0.38) | HMGCRGAATHRBTHRAHSD11B1 | |
| SCHEMBL7079979 | 0.84 | HMGCR (0.42) | HMGCRTHRBTHRAL3MBTL1 | |
| SCHEMBL7133257 | 0.76 | HMGCR (0.62) | HMGCRPOLBGAAEPHX2KDM4E | |
| SCHEMBL6451333 | 0.73 | PPARA (0.46) | — | |
| SCHEMBL5762437 | 0.72 | KMT2A (0.35) | L3MBTL1KDM4EALDH1A1LMNA | |
| SCHEMBL3373090 | 0.71 | NLRP3 (0.36) | HSD11B1HSD17B2KDM4E | |
| SCHEMBL11267610 | 0.70 | MAOB (0.42) | GAATHRBTHRAKDM4EALDH1A1 | |
| SCHEMBL5664710 | 0.70 | HMGCR (0.57) | HMGCRPOLBGAAEPHX2 | |
| SCHEMBL15807576 | 0.69 | NLRP3 (0.38) | POLBGAAHSD11B1HSD17B2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326618-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | Ilex Oncology Research S.A. (CH) | 2003-07-16 | — | — | EP | claimed |
| WO-2002011704-A2 | USE OF ARYL-SUBSTITUTED 1,1-DIPHOSPHONATES FOR THE TREATMENT OF BONE DISEASES | SYMPHAR S.A. (CH) | 2002-02-14 | — | — | WO | claimed |