SCHEMBL7080458

SCHEMBL7080458

COC(=O)Oc1ccc2ccccc2c1OCOCC[Si](C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.41
HPGD P15428 2/20 0.41
KDM4E B2RXH2 1/20 0.41
KMT2A Q03164 1/20 0.38
NCEH1 Q6PIU2 6/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
NPC1 O15118 1/20 0.37
MAPT P10636 1/20 0.37
RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7083483 0.87 ALDH1A1 (0.40) ALDH1A1HPGDKDM4EKMT2ANCEH1
SCHEMBL6042078 0.82 HDAC3 (0.56) ALDH1A1HPGDKDM4EKMT2ASMN1; SMN2
SCHEMBL4419587 0.80 ALDH1A1 (0.39) ALDH1A1HPGDKDM4ESMN1; SMN2NPC1
SCHEMBL7076825 0.79 MTNR1A (0.42) ALDH1A1HPGDKDM4E
SCHEMBL6042598 0.78 SLC2A1 (0.39) ALDH1A1HPGDKDM4EKMT2AHDAC3
SCHEMBL7080245 0.77 CTSD (0.39) ALDH1A1HPGDKDM4EKMT2ANCEH1
SCHEMBL6938277 0.75 NCEH1 (0.52) ALDH1A1HPGDKDM4ENCEH1SMN1; SMN2
SCHEMBL3069372 0.75 ALDH1A1 (0.52) ALDH1A1KDM4ENCEH1SMN1; SMN2NPC1
SCHEMBL6042329 0.74 SLC2A1 (0.36)
SCHEMBL7075190 0.74 CYP2D6 (0.42) ALDH1A1HPGDKDM4ESMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0863875-B1 NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY HOFFMANN LA ROCHE (CH) 2003-06-04 EP disclosed
EP-0863875-A1 NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY F. HOFFMANN-LA ROCHE AG (CH) 1998-09-16 EP disclosed
WO-1997009311-A1 NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY F. HOFFMANN-LA ROCHE AG (CH) 1997-03-13 WO disclosed