Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 7/20 | 0.52 |
| ▸ | DRD3 | P35462 | 6/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6955921 | 0.99 | SIGMAR1 (0.56) | SIGMAR1DRD2DRD3HTR1AHTR7 | |
| SCHEMBL7084707 | 0.91 | SIGMAR1 (0.57) | SIGMAR1DRD2DRD3HTR1AADRA1A | |
| Hydrochloric Acid SCHEMBL6950577 | 0.90 | SIGMAR1 (0.56) | SIGMAR1DRD2DRD3HTR1AADRA1A | |
| SCHEMBL7080017 | 0.84 | DRD2 (0.58) | SIGMAR1DRD2DRD3HTR1AADRA1A | |
| SCHEMBL7077525 | 0.84 | DRD2 (0.49) | DRD2DRD3HTR1AHTR7ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6957049 | 0.84 | DRD2 (0.57) | SIGMAR1DRD2DRD3HTR1AADRA1A | |
| Hydrochloric Acid SCHEMBL6956332 | 0.83 | DRD2 (0.49) | DRD2DRD3HTR1AHTR7ALDH1A1 | |
| SCHEMBL7081171 | 0.81 | SIGMAR1 (0.56) | SIGMAR1DRD2DRD3HTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL6959307 | 0.81 | SIGMAR1 (0.56) | SIGMAR1DRD2DRD3HTR1ADRD4 | |
| SCHEMBL9164109 | 0.73 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851862-B1 | 1(HETERO)ARYL-4-(CONDENSED THIAZOL-2-YLALKYL)-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF 5-HT1A-RECEPTOR MEDIATED DISORDERS | PHARMACIA ITALIA SPA (IT) | 2003-09-10 | — | — | EP | claimed |