Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6950577 | 0.99 | SIGMAR1 (0.56) | SIGMAR1HTR1AADRA1ADRD2DRD4 | |
| SCHEMBL7081265 | 0.91 | SIGMAR1 (0.57) | SIGMAR1HTR1AADRA1ADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL6955921 | 0.90 | SIGMAR1 (0.56) | SIGMAR1HTR1AADRA1ADRD2DRD4 | |
| SCHEMBL6952207 | 0.83 | HTR1A (0.49) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL6959796 | 0.82 | HTR1A (0.48) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL7082241 | 0.81 | SIGMAR1 (0.52) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL6956636 | 0.80 | DRD2 (0.52) | SIGMAR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL6952045 | 0.80 | DRD3 (0.53) | SIGMAR1HTR1AADRA1ADRD2DRD4 | |
| SCHEMBL7081496 | 0.79 | HTR1A (0.44) | SIGMAR1HTR1AADRA1ADRD2DRD4 | |
| Hydrochloric Acid SCHEMBL6960476 | 0.79 | DRD3 (0.52) | SIGMAR1HTR1AADRA1ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0851862-B1 | 1(HETERO)ARYL-4-(CONDENSED THIAZOL-2-YLALKYL)-PIPERAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF 5-HT1A-RECEPTOR MEDIATED DISORDERS | PHARMACIA ITALIA SPA (IT) | 2003-09-10 | — | — | EP | claimed |