Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501551 | 0.75 | CYP3A4 (0.52) | NPSR1TP53 | |
| SCHEMBL8525528 | 0.74 | MMP13 (0.43) | — | |
| SCHEMBL8498354 | 0.74 | MMP9 (0.50) | — | |
| SCHEMBL7212256 | 0.71 | NPSR1 (0.38) | NPSR1USP2 | |
| SCHEMBL22722982 | 0.67 | — | — | |
| SCHEMBL4892039 | 0.66 | NPSR1 (0.67) | NPSR1 | |
| SCHEMBL20447427 | 0.65 | NPSR1 (0.59) | NPSR1TP53 | |
| SCHEMBL21797972 | 0.64 | NPSR1 (0.53) | NPSR1TP53 | |
| SCHEMBL998215 | 0.63 | HPGD (0.35) | NPSR1USP2 | |
| SCHEMBL6816556 | 0.62 | NPSR1 (0.41) | NPSR1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326600-A2 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | Curis, Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030421-A2 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO | CURIS, INC. (US) | 2002-04-18 | — | — | WO | disclosed |