SCHEMBL7083103

SCHEMBL7083103

CNCc1nc(C(C)C)c(Sc2ccccc2)n1Cc1cccnc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5AP P20292 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36
KCNH2 Q12809 1/20 0.36
TLR7 Q9NYK1 2/20 0.35
LTA4H P09960 1/20 0.34
EPHX2 P34913 1/20 0.34
PRMT6 Q96LA8 1/20 0.34
HTT P42858 1/20 0.34
KMT2A Q03164 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TP53 P04637 1/20 0.34
BLM P54132 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPK1 P28482 1/20 0.33
RECQL P46063 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6961326 0.88 GRIN1 (0.39) EPHX2PRMT6KMT2AALDH1A1S1PR3
SCHEMBL6965333 0.88 ALDH1A1 (0.41) EPHX2PRMT6HTTKMT2ASMN1; SMN2
SCHEMBL6960328 0.88 ALDH1A1 (0.37) ALOX5APCYP3A4CYP2D6TLR7PRMT6
SCHEMBL7086713 0.88 KMT2A (0.35) CYP3A4CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL6971326 0.88 HTT (0.41) CYP3A4HTTKMT2ASMN1; SMN2L3MBTL1
SCHEMBL6961249 0.88 GRIN1 (0.38) CYP3A4CYP2D6SLC6A2SLC6A4SLC6A3
SCHEMBL7081083 0.87 ALOX5AP (0.37) ALOX5APTLR7SMN1; SMN2BLMALDH1A1
SCHEMBL6972848 0.87 TLR7 (0.38) ALOX5APCYP3A4CYP2D6SLC6A2SLC6A4
SCHEMBL7087408 0.87 POLB (0.38) TLR7HTTKMT2ASMN1; SMN2ALDH1A1
SCHEMBL8109122 0.87 RECQL (0.47) CYP3A4HTTKMT2ASMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed