SCHEMBL7083150

SCHEMBL7083150

CCC(OC(C)=O)c1nc(C(C)C)c(Sc2cccc([N+](=O)[O-])c2)[nH]1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 8/20 0.38
HSP90AA1 P07900 1/20 0.35
LMNA P02545 3/20 0.35
ALDH1A1 P00352 2/20 0.35
PKM P14618 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CACNA1F O60840 6/20 0.34
CACNA1D Q01668 6/20 0.34
CACNA1S Q13698 6/20 0.34
CYP2C9 P11712 3/20 0.34
CYP2C19 P33261 3/20 0.34
CYP2D6 P10635 2/20 0.34
RECQL P46063 1/20 0.34
ADORA3 P0DMS8 1/20 0.34
MEN1 O00255 2/20 0.33
CYP1A2 P05177 2/20 0.33
CYP3A4 P08684 2/20 0.33
KMT2A Q03164 2/20 0.33
MAPT P10636 2/20 0.33
NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6971934 0.89 CACNA1C (0.35) CACNA1CHSP90AA1LMNAPKMSMN1; SMN2
SCHEMBL6969750 0.89 HSP90AA1 (0.38) CACNA1CHSP90AA1LMNAALDH1A1SMN1; SMN2
SCHEMBL7084594 0.86 CYP1A2 (0.38) LMNAALDH1A1PKMSMN1; SMN2MEN1
SCHEMBL6972999 0.86 RXFP1 (0.37) LMNAALDH1A1SMN1; SMN2CYP2C9CYP2C19
SCHEMBL6971992 0.86 HSP90AA1 (0.34) CACNA1CHSP90AA1LMNAALDH1A1PKM
SCHEMBL6974133 0.85 CACNA1C (0.36) CACNA1CHSP90AA1LMNAALDH1A1PKM
SCHEMBL6974498 0.85 SLC6A9 (0.35) LMNAALDH1A1
SCHEMBL7081642 0.85 TP53 (0.39) LMNAMEN1KMT2AMAPTHPGD
SCHEMBL6975315 0.84 HSP90AA1 (0.39) CACNA1CHSP90AA1LMNAALDH1A1PKM
SCHEMBL6974480 0.84 DHFR (0.34) ALDH1A1KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed