SCHEMBL6971934

SCHEMBL6971934

CCC(OCCOC(C)=O)c1nc(C(C)C)c(Sc2cccc([N+](=O)[O-])c2)[nH]1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 9/20 0.35
CACNA1F O60840 8/20 0.35
CACNA1D Q01668 8/20 0.35
CACNA1S Q13698 8/20 0.35
CYP2C9 P11712 3/20 0.35
CYP2C19 P33261 3/20 0.35
MEN1 O00255 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
KMT2A Q03164 2/20 0.35
LMNA P02545 2/20 0.35
CYP2D6 P10635 2/20 0.35
MAPT P10636 2/20 0.35
TSHR P16473 1/20 0.35
NFKB1 P19838 1/20 0.35
THPO P40225 1/20 0.35
RECQL P46063 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
HSP90AA1 P07900 1/20 0.32
PKM P14618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7085474 0.91 CYP2C9 (0.38) CACNA1CCACNA1FCACNA1DCACNA1SCYP2C9
SCHEMBL6971992 0.90 HSP90AA1 (0.34) CACNA1CCACNA1FCACNA1DCACNA1SCYP2C9
SCHEMBL6967395 0.89 MEN1 (0.35) CACNA1CCACNA1FCACNA1DCACNA1SCYP2C9
SCHEMBL7083150 0.89 CACNA1C (0.38) CACNA1CCACNA1FCACNA1DCACNA1SCYP2C9
SCHEMBL6975428 0.88 CYP1A2 (0.35) CYP2C9CYP2C19MEN1CYP1A2CYP3A4
SCHEMBL6962571 0.87 RXFP1 (0.36) CYP2C9CYP2C19MEN1CYP1A2CYP3A4
SCHEMBL7084539 0.86 SLC6A9 (0.33) LMNA
SCHEMBL7086458 0.86 TP53 (0.36) LMNA
SCHEMBL7086334 0.86 DHFR (0.32) CYP2C9CYP2C19MEN1CYP1A2KMT2A
SCHEMBL6969750 0.81 HSP90AA1 (0.38) CACNA1CCYP2C9CYP2C19MEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed