Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737044 | 0.85 | KCNH2 (0.51) | KCNH2EPHX2MGLLHPGDALDH1A1 | |
| SCHEMBL3785456 | 0.84 | KCNH2 (0.56) | KCNH2EPHX2MGLLHPGDALDH1A1 | |
| SCHEMBL6956593 | 0.84 | KCNH2 (0.56) | KCNH2EPHX2MGLLHPGDALDH1A1 | |
| SCHEMBL5735700 | 0.83 | KCNH2 (0.49) | KCNH2EPHX2MGLLHPGDALDH1A1 | |
| SCHEMBL6957897 | 0.81 | KCNH2 (0.52) | KCNH2EPHX2MGLLHPGDALDH1A1 | |
| SCHEMBL6597949 | 0.81 | MIF (0.45) | KCNH2EPHX2HPGDALDH1A1KDM4E | |
| SCHEMBL14924128 | 0.80 | MIF (0.41) | KCNH2LMNAKDM4EMAPT | |
| SCHEMBL5735272 | 0.79 | KCNH2 (0.60) | KCNH2EPHX2MGLLHPGDALDH1A1 | |
| SCHEMBL5737999 | 0.76 | KCNH2 (0.50) | KCNH2EPHX2MGLLHPGDALDH1A1 | |
| SCHEMBL9463558 | 0.76 | KCNH2 (0.65) | KCNH2EPHX2MGLLHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6602889-B1 | 5-heteroaryl substituted indoles | H. LUNDBECK A.S. (DK) | 2003-08-05 | — | — | US | disclosed |
| EP-1068198-B1 | 5-HETEROARYL SUBSTITUTED INDOLES | LUNDBECK & CO AS H (DK) | 2003-05-28 | — | — | EP | disclosed |