Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Tributyl Citrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.36 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL18832702 | 0.95 | NAAA (0.45) | ALDH1A1NAAAKDM4EHCAR2BLM | |
| SCHEMBL1412782 | 0.95 | NAAA (0.42) | ALDH1A1NAAAATMHCAR2TSHR | |
| Citric Acid SCHEMBL25266373 | 0.94 | ALDH1A1 (0.52) | ALDH1A1NAAAATMKDM4EHCAR2 | |
| SCHEMBL317666 | 0.94 | ALDH1A1 (0.52) | ALDH1A1NAAAATMKDM4EHCAR2 | |
| Ammonia Solution, Strong SCHEMBL6657318 | 0.91 | ALDH1A1 (0.48) | ALDH1A1NAAAATMKDM4EHCAR2 | |
| SCHEMBL417321 | 0.89 | NAAA (0.51) | NAAAHCAR2TSHRDGKARAD52 | |
| SCHEMBL1958036 | 0.89 | NAAA (0.51) | NAAAHCAR2TSHRDGKARAD52 | |
| SCHEMBL6288811 | 0.89 | NAAA (0.51) | NAAAHCAR2TSHRDGKARAD52 | |
| SCHEMBL1218290 | 0.89 | NAAA (0.51) | NAAAHCAR2TSHRDGKARAD52 | |
| SCHEMBL25201606 | 0.89 | ALDH1A1 (0.47) | ALDH1A1NAAAATMKDM4EHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109072514-A | Guided bone regeneration nano-fiber composite film and preparation method thereof | 阿莫绿色技术有限公司 | 2018-12-21 | — | — | CN | claimed |
| US-10604472-B2 | Auto-catalyzed process for the synthesis of tributyl citrate (TBC) | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-03-31 | — | — | US | disclosed |
| US-20180354886-A1 | AN AUTO-CATALYZED PROCESS FOR THE SYNTHESIS OF TRIBUTYL CITRATE (TBC) | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-12-13 | — | — | US | disclosed |
| CN-104220534-B | Biodegradable resin composition containing environmentally friendly plasticizer and biodegradable resin product using same | 乐金华奥斯有限公司 | 2017-10-20 | — | — | CN | disclosed |
| CN-105764472-A | Glycerol-in-oil emulsion | 雅芳产品公司 | 2016-07-13 | — | — | CN | disclosed |
| CN-104892418-A | Synthesis method of citric acid tributyl citrate | HUNAN ER KANG PHARMACEUTICAL CO LTD | 2015-09-09 | — | — | CN | disclosed |
| CN-104892418-A | Synthesis method of citric acid tributyl citrate | HUNAN ER KANG PHARMACEUTICAL CO LTD | 2015-09-09 | — | — | CN | disclosed |
| CN-100404495-C | Tributyl citrate preparation method using ion liquid catalysis | UNIV TSINGHUA (CN) | 2008-07-23 | — | — | CN | disclosed |
| EP-1035862-B1 | CYCLOSPORIN-CONTAINING MICROEMULSION PRECONCENTRATE COMPOSITION | CHONG KUN DANG PHARM CORP (KR) | 2003-07-09 | — | — | EP | disclosed |
| US-5695772-A | CLARITY; MIXTURE OF WATER, POLYHYDRIC ALCOHOL, POLYBUTENE AND SILICONE | CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) | 1997-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180354886-A1 | AN AUTO-CATALYZED PROCESS FOR THE SYNTHESIS OF TRIBUTYL CITRATE (TBC) | TBC1D5, TBC1D15, PC | MEN1 1728/4885ESR1 2267/4885ESR2 2134/4885 |
| US-10604472-B2 | Auto-catalyzed process for the synthesis of tributyl citrate (TBC) | TBC1D5, TBC1D15, PC | MEN1 1836/4885ESR1 2247/4885ESR2 2197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.