Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7079646 | 0.94 | REN (0.34) | RENPRMT5WDR77HPGDPDE4B | |
| SCHEMBL7082266 | 0.90 | REN (0.38) | RENPRMT5PDE4B | |
| SCHEMBL7081100 | 0.90 | PRMT5 (0.33) | RENPRMT5WDR77HPGDTACR1 | |
| SCHEMBL7081778 | 0.89 | SLC6A1 (0.32) | RENTACR1 | |
| SCHEMBL7079227 | 0.88 | REN (0.33) | RENPRMT5WDR77HPGDPDE4B | |
| SCHEMBL7080748 | 0.86 | REN (0.42) | RENHPGDPDE4B | |
| SCHEMBL7076769 | 0.85 | REN (0.45) | REN | |
| SCHEMBL6041481 | 0.84 | HPGD (0.36) | RENPRMT5WDR77HPGDPDE4B | |
| SCHEMBL7080086 | 0.83 | REN (0.31) | REN | |
| SCHEMBL27502531 | 0.82 | PRMT5 (0.36) | RENPRMT5WDR77HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-B1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | HOFFMANN LA ROCHE (CH) | 2003-06-04 | — | — | EP | disclosed |