Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5960435 | 0.93 | HRH3 (0.50) | POLBSIGMAR1HRH1THRBHRH3 | |
| SCHEMBL16026529 | 0.89 | THRB (0.61) | HRH1THRBHRH3HSD17B10 | |
| SCHEMBL29922137 | 0.89 | THRB (0.61) | HRH1THRBHRH3HSD17B10 | |
| SCHEMBL19597688 | 0.89 | POLB (0.59) | POLBSIGMAR1ALDH1A1L3MBTL1 | |
| SCHEMBL5714434 | 0.89 | L3MBTL1 (0.63) | POLBSIGMAR1HRH1HRH3ALDH1A1 | |
| SCHEMBL29263723 | 0.86 | HRH3 (0.48) | POLBSIGMAR1HRH1THRBHRH3 | |
| SCHEMBL29263649 | 0.83 | GRIN2B (0.50) | POLBSIGMAR1HRH1HRH3ALDH1A1 | |
| SCHEMBL12359541 | 0.82 | THRB (0.56) | SIGMAR1HRH1THRBHRH3HSD17B10 | |
| SCHEMBL868571 | 0.81 | HRH3 (0.56) | SIGMAR1HRH1THRBHRH3ALDH1A1 | |
| SCHEMBL8648859 | 0.81 | DRD2 (0.68) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000046-B1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI CHEM PHARM (CH) | 2003-11-26 | — | — | EP | disclosed |