Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 3/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4875247 | 0.94 | CYP3A4 (0.34) | ADAMTS5ALDH1A1LMNACCR5 | |
| SCHEMBL4875582 | 0.93 | CCR5 (0.36) | ADAMTS5RORCPLA2G2AALDH1A1PTGS2 | |
| SCHEMBL4875551 | 0.91 | CHRM2 (0.36) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4876417 | 0.91 | GPR119 (0.39) | LMNASMN1; SMN2 | |
| SCHEMBL4865388 | 0.89 | NPY2R (0.39) | ADAMTS5RORC | |
| SCHEMBL4874459 | 0.89 | HRH2 (0.33) | ADAMTS5PLA2G2AALDH1A1PTGS2SIRT2 | |
| SCHEMBL4873761 | 0.89 | RORC (0.34) | ADAMTS5RORCPLA2G2AALDH1A1PTGS2 | |
| SCHEMBL4872361 | 0.89 | GPR119 (0.33) | LMNASMN1; SMN2 | |
| SCHEMBL4870274 | 0.88 | GPR119 (0.36) | PLA2G2ALMNASMN1; SMN2 | |
| SCHEMBL4870335 | 0.88 | GPR119 (0.36) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001090081-A1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-29 | — | — | WO | disclosed |