Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.60 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.60 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29369522 | 0.74 | ADORA3 (0.60) | ADORA3ADORA2ATOP2AROCK2MAPT | |
| SCHEMBL7082174 | 0.74 | ADORA3 (0.60) | ADORA3ADORA2ATOP2AROCK2MAPT | |
| SCHEMBL7083487 | 0.74 | ADORA3 (0.60) | ADORA3ADORA2ATOP2AROCK2MAPT | |
| SCHEMBL1609661 | 0.72 | ADORA3 (0.54) | ADORA3ADORA2ATOP2AROCK2NFATC1 | |
| SCHEMBL11490005 | 0.70 | ADORA3 (0.62) | ADORA3ADORA2ATOP2AROCK2MAPT | |
| SCHEMBL6046305 | 0.69 | ADORA3 (0.54) | ADORA3ADORA2AROCK2MAPTNFATC1 | |
| SCHEMBL21807233 | 0.68 | ADORA3 (0.42) | ADORA3ADORA2AROCK2MAPTKDM5A | |
| SCHEMBL7082459 | 0.68 | ADORA3 (0.57) | ADORA3ADORA2AKDM5AKDM4EALDH1A1 | |
| SCHEMBL29856387 | 0.67 | SLC22A12 (0.46) | ADORA3ADORA2AROCK2SLC22A12KDM5A | |
| Bauerine B SCHEMBL3305155 | 0.67 | SIRT2 (0.44) | ADORA3ADORA2AROCK2CYP19A1NFATC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030148259-A1 | Method of identifying insulin secretion stimulating compounds, and the use of such compounds in treating insulin-secretion related disorders | KAROLINSKA INNOVATIONS AB (SE) | 2003-08-07 | — | — | US | claimed |
| WO-2003065036-A1 | METHOD OF IDENTIFYING INSULIN SECRETION STIMULATING COMPOUNDS, AND THE USE OF SUCH COMPOUNDS IN TREATING INSULIN-SECRETION RELATED DISORDERS | KAROLINSKA INNOVATIONS AB (SE) | 2003-08-07 | — | — | WO | claimed |
| US-20030148259-A1 | Method of identifying insulin secretion stimulating compounds, and the use of such compounds in treating insulin-secretion related disorders | KAROLINSKA INNOVATIONS AB (SE) | 2003-08-07 | — | — | US | disclosed |
| WO-2003065036-A1 | METHOD OF IDENTIFYING INSULIN SECRETION STIMULATING COMPOUNDS, AND THE USE OF SUCH COMPOUNDS IN TREATING INSULIN-SECRETION RELATED DISORDERS | KAROLINSKA INNOVATIONS AB (SE) | 2003-08-07 | — | — | WO | disclosed |