Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4495436 | 0.85 | ATM (0.55) | ALDH1A1KMT2AGAAMAPTMEN1 | |
| SCHEMBL7255769 | 0.80 | ALDH1A1 (0.60) | ALDH1A1KMT2AGAAMAPTMEN1 | |
| SCHEMBL4500342 | 0.77 | MAPT (0.68) | ALDH1A1KMT2AGAAMAPTMEN1 | |
| SCHEMBL7088161 | 0.77 | GAA (0.55) | ALDH1A1KMT2AGAAMAPTMEN1 | |
| SCHEMBL4471375 | 0.73 | GAA (0.61) | ALDH1A1KMT2AGAAMAPTMEN1 | |
| SCHEMBL4465659 | 0.73 | KMT2A (0.43) | ALDH1A1KMT2AGAAMAPTMEN1 | |
| SCHEMBL2561137 | 0.71 | MAPT (0.47) | ALDH1A1KMT2AGAAMAPTMEN1 | |
| SCHEMBL4511434 | 0.70 | GAA (0.54) | ALDH1A1KMT2AGAAMAPTMEN1 | |
| SCHEMBL2574933 | 0.70 | MAPT (0.52) | ALDH1A1KMT2AGAAMAPTMEN1 | |
| SCHEMBL26756671 | 0.70 | MAPT (0.58) | ALDH1A1KMT2AGAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030232813-A1 | Novel amino substituted pyrimidinone derivatives | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2003-12-18 | — | — | US | disclosed |
| WO-2003084936-A2 | AMINO SUBSTITUTED PYRIMIDINONE DERIVATIVES USEFUL IN THE TREATMENT OF INFLAMMATION AND IMMUNOLOGICAL | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232813-A1 | Novel amino substituted pyrimidinone derivatives | TPMT, TYMP, CYP3A5 | ALDH1A1 596/4885KMT2A 3187/4885GAA 1958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.