Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4465659 | 0.86 | KMT2A (0.43) | ATMALDH1A1KMT2AGAAMAPT | |
| SCHEMBL7084232 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KMT2AGAAMAPTHPGD | |
| SCHEMBL9381308 | 0.84 | ATM (0.73) | ATMALDH1A1KMT2AGAAMAPT | |
| SCHEMBL7255769 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KMT2AGAAMAPTHPGD | |
| SCHEMBL7088161 | 0.80 | GAA (0.55) | ALDH1A1KMT2AGAAMAPTHPGD | |
| SCHEMBL4500342 | 0.80 | MAPT (0.68) | ATMALDH1A1KMT2AGAAMAPT | |
| SCHEMBL4457582 | 0.77 | KMT2A (0.55) | ATMALDH1A1KMT2AMAPTHPGD | |
| SCHEMBL1958423 | 0.76 | GAA (0.59) | ALDH1A1KMT2AGAAMAPTHPGD | |
| SCHEMBL4498185 | 0.74 | ALDH1A1 (0.68) | ALDH1A1KMT2AGAAMAPTHPGD | |
| SCHEMBL4511434 | 0.73 | GAA (0.54) | ALDH1A1KMT2AGAAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090286813-A1 | Thioxanthine Derivatives and Their Use as Inhibitors of MPO | ASTRAZENECA AB (SE) | 2009-11-19 | — | — | US | disclosed |
| US-20030232813-A1 | Novel amino substituted pyrimidinone derivatives | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2003-12-18 | — | — | US | disclosed |
| WO-2003084936-A2 | AMINO SUBSTITUTED PYRIMIDINONE DERIVATIVES USEFUL IN THE TREATMENT OF INFLAMMATION AND IMMUNOLOGICAL | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286813-A1 | Thioxanthine Derivatives and Their Use as Inhibitors of MPO | MPO, XDH, EPX | ATM 1511/4885ALDH1A1 296/4885KMT2A 2979/4885 |
| US-20030232813-A1 | Novel amino substituted pyrimidinone derivatives | TPMT, TYMP, CYP3A5 | ATM 2207/4885ALDH1A1 596/4885KMT2A 3187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.