Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.61 |
| ▸ | CCR5 | P51681 | 8/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL340916 | 0.90 | HTR2A (0.67) | HTR2AKCNH2 | |
| SCHEMBL7603229 | 0.89 | MEN1 (0.63) | HTR2ACCR5MEN1KMT2AKCNH2 | |
| SCHEMBL340673 | 0.85 | HTR2A (0.63) | HTR2AKCNH2 | |
| SCHEMBL341871 | 0.85 | OPRM1 (0.66) | HTR2ACCR5 | |
| SCHEMBL6613844 | 0.84 | CCR5 (0.60) | CCR5MEN1KMT2AKCNH2CYP2D6 | |
| SCHEMBL342280 | 0.84 | HTR2A (0.78) | HTR2AKCNH2 | |
| SCHEMBL6705240 | 0.83 | KCNH2 (0.62) | CCR5KCNH2GPR119 | |
| SCHEMBL340598 | 0.83 | HTR2A (0.61) | HTR2AKCNH2GPR119 | |
| SCHEMBL342684 | 0.83 | HTR2A (0.61) | HTR2AKCNH2GPR119 | |
| SCHEMBL4164384 | 0.83 | MEN1 (0.56) | HTR2ACCR5MEN1KMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289957-A1 | PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES, IN PARTICULAR AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001087839-A1 | PHARMACEUTICALLY ACTIVE PIPERIDINE DERIVATIVES, IN PARTICULAR AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2001-11-22 | — | — | WO | disclosed |