Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.62 |
| ▸ | CCR5 | P51681 | 8/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5083771 | 0.93 | OPRM1 (0.69) | KCNH2GPR119CCR5OPRM1SIGMAR1 | |
| SCHEMBL6703964 | 0.86 | KCNH2 (0.79) | KCNH2GPR119CCR5SIGMAR1CHRM2 | |
| SCHEMBL2768189 | 0.86 | KCNH2 (0.80) | KCNH2GPR119CCR5 | |
| SCHEMBL9994976 | 0.85 | OPRM1 (0.71) | CCR5OPRM1TMEM97 | |
| SCHEMBL7084347 | 0.83 | HTR2A (0.61) | KCNH2GPR119CCR5 | |
| SCHEMBL7603229 | 0.83 | MEN1 (0.63) | KCNH2GPR119CCR5 | |
| SCHEMBL6755243 | 0.82 | CCR5 (0.55) | KCNH2CCR5OPRM1TMEM97 | |
| SCHEMBL6613844 | 0.80 | CCR5 (0.60) | KCNH2GPR119CCR5OPRM1CHRM2 | |
| SCHEMBL7601798 | 0.80 | L3MBTL1 (0.64) | CCR5OPRM1 | |
| SCHEMBL9654034 | 0.80 | OPRM1 (0.67) | CCR5OPRM1SIGMAR1CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040006081-A1 | Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2004-01-08 | — | — | US | disclosed |
| CN-1441781-A | Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity | ASTRAZENECA AG (SE) | 2003-09-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040006081-A1 | Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity | CCR5, CCR2, CCR1 | KCNH2 3181/4885GPR119 169/4885CCR5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.