Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975744 | 0.88 | METAP2 (0.42) | METAP2CCR4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7085330 | 0.85 | LRRK2 (0.43) | METAP2CCR4CCNKCCND3CDK9 | |
| SCHEMBL5376479 | 0.82 | METAP2 (0.46) | METAP2CCR4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL6615397 | 0.82 | METAP2 (0.49) | METAP2CCR4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7087916 | 0.80 | CCR4 (0.39) | METAP2CCR4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7083096 | 0.76 | CCR4 (0.39) | METAP2CCR4PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7084581 | 0.76 | NPC1 (0.40) | METAP2NPC1GAAMAPTRAB9A | |
| SCHEMBL7090453 | 0.75 | NFKB1 (0.46) | CCR4PIK3CAPIK3CBPIK3CGEGFR | |
| SCHEMBL5371746 | 0.75 | KMT2A (0.42) | METAP2PIK3CAPIK3CBPIK3CGNPC1 | |
| SCHEMBL7089876 | 0.75 | SMN1; SMN2 (0.44) | METAP2CCR4IGF1RNPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1223932-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | claimed |
| EP-1223932-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2002-07-24 | — | — | EP | claimed |
| WO-2001024796-A1 | 1,2,4-TRIAZOLE DERIVATIVES, COMPOSITION, PROCESS OF MAKING AND METHODS OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-12 | — | — | WO | claimed |