Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | METAP2 | P50579 | 4/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.37 |
| ▸ | CDK2 | P24941 | 5/20 | 0.37 |
| ▸ | CCNK | O75909 | 3/20 | 0.37 |
| ▸ | CCND3 | P30281 | 3/20 | 0.37 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089876 | 0.89 | SMN1; SMN2 (0.44) | LRRK2NPSR1LMNAHTTSMN1; SMN2 | |
| SCHEMBL7084460 | 0.85 | METAP2 (0.41) | SMN1; SMN2METAP2CCNKCCND3CDK9 | |
| SCHEMBL7084581 | 0.81 | NPC1 (0.40) | NPSR1LMNAHTTSMN1; SMN2METAP2 | |
| SCHEMBL5387206 | 0.81 | METAP2 (0.41) | LRRK2NPSR1LMNAHTTSMN1; SMN2 | |
| SCHEMBL7090453 | 0.80 | NFKB1 (0.46) | HTTCCNA2CDK2CCR4MAPT | |
| SCHEMBL7089232 | 0.79 | PKM (0.42) | LRRK2NPSR1LMNAHTTSMN1; SMN2 | |
| SCHEMBL6976057 | 0.77 | MAPT (0.45) | LRRK2NPSR1LMNAHTTSMN1; SMN2 | |
| SCHEMBL6975744 | 0.77 | METAP2 (0.42) | NPSR1LMNAHTTSMN1; SMN2METAP2 | |
| SCHEMBL7090147 | 0.76 | SYK (0.41) | LMNASMN1; SMN2MAPTMAPK1NPC1 | |
| SCHEMBL7087036 | 0.76 | MAPT (0.45) | NPSR1LMNASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1223932-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | claimed |
| EP-1223932-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2002-07-24 | — | — | EP | claimed |
| WO-2001024796-A1 | 1,2,4-TRIAZOLE DERIVATIVES, COMPOSITION, PROCESS OF MAKING AND METHODS OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-12 | — | — | WO | claimed |
| EP-1223932-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2003-01-15 | — | — | EP | disclosed |
| EP-1223932-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001024796-A1 | 1,2,4-TRIAZOLE DERIVATIVES, COMPOSITION, PROCESS OF MAKING AND METHODS OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-12 | — | — | WO | disclosed |