Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PLD1 | Q13393 | 3/20 | 0.37 |
| ▸ | PLD2 | O14939 | 2/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085096 | 0.79 | POLB (0.44) | POLBPLD1PLD2MEN1CYP1A2 | |
| SCHEMBL8524117 | 0.72 | PLD2 (0.36) | PLD1PLD2OPRM1OPRL1CHRM1 | |
| SCHEMBL7081245 | 0.70 | TAAR1 (0.40) | P2RX7LMNACYP2D6 | |
| SCHEMBL9784844 | 0.69 | GSK3B (0.35) | — | |
| SCHEMBL10423416 | 0.67 | POLB (0.42) | POLBPLD1PLD2PAX8MEN1 | |
| SCHEMBL17103086 | 0.66 | SLC6A2 (0.36) | DRD2SLC6A2SLC6A4 | |
| SCHEMBL8470458 | 0.66 | SLC6A2 (0.36) | POLBMEN1KMT2ALMNADRD2 | |
| SCHEMBL14622076 | 0.64 | POLB (0.67) | POLBMEN1CYP1A2KMT2AOPRM1 | |
| SCHEMBL7443237 | 0.63 | POLB (0.70) | POLBPLD1MEN1CYP1A2KMT2A | |
| SCHEMBL10349652 | 0.63 | PDE10A (0.40) | MEN1KMT2ACYP2D6DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775118-B1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-0765320-B1 | BENZIMIDAZOLONE DERIVATIVES WITH CENTRAL DOPAMINERGIC ACTIVITY | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-0775118-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0765320-A1 | BENZIMIDAZOLONE DERIVATIVES WITH CENTRAL DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1996004250-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1996-02-15 | — | — | WO | disclosed |
| WO-1995034555-A1 | BENZIMIDAZOLONE DERIVATIVES WITH CENTRAL DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1995-12-21 | — | — | WO | disclosed |