Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17103086 | 0.72 | SLC6A2 (0.36) | — | |
| SCHEMBL9784844 | 0.72 | GSK3B (0.35) | PDE10AGSK3B | |
| SCHEMBL7085098 | 0.70 | POLB (0.39) | CYP2D6LMNAP2RX7 | |
| SCHEMBL10349652 | 0.69 | PDE10A (0.40) | CYP2D6PDE10AALDH1A1KDM4EGSK3B | |
| Hydrochloric Acid SCHEMBL10382640 | 0.68 | GSK3B (0.40) | CYP2D6PDE10AALDH1A1KDM4EGSK3B | |
| SCHEMBL19629766 | 0.67 | PDE10A (0.38) | TSHRPDE10AKDM4EGSK3B | |
| SCHEMBL11707727 | 0.67 | OPRD1 (0.37) | PDE10AALDH1A1KDM4EGSK3B | |
| SCHEMBL21498090 | 0.67 | KDM4E (0.40) | CYP2D6PDE10AALDH1A1KDM4EGSK3B | |
| SCHEMBL18250744 | 0.66 | HTT (0.55) | CYP2D6LMNASMN1; SMN2HTTTSHR | |
| Hydrochloric Acid SCHEMBL19875629 | 0.66 | MAPK1 (0.47) | HTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775118-B1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-0765320-B1 | BENZIMIDAZOLONE DERIVATIVES WITH CENTRAL DOPAMINERGIC ACTIVITY | PFIZER (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-0765320-A1 | BENZIMIDAZOLONE DERIVATIVES WITH CENTRAL DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995034555-A1 | BENZIMIDAZOLONE DERIVATIVES WITH CENTRAL DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1995-12-21 | — | — | WO | disclosed |