Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8470455 | 0.76 | SLC6A2 (0.43) | SLC6A2SLC6A4PGRDRD2DRD3 | |
| SCHEMBL7085098 | 0.66 | POLB (0.39) | SLC6A2SLC6A4LMNAPOLBDRD2 | |
| SCHEMBL6909258 | 0.63 | PGR (0.57) | SLC6A2SLC6A4KDM4EALDH1A1PGR | |
| SCHEMBL8407506 | 0.61 | KDM4E (0.49) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL4668715 | 0.61 | CACNA1G (0.50) | SLC6A2SLC6A4ALDH1A1LMNAPGR | |
| SCHEMBL1829565 | 0.60 | LTA4H (0.54) | POLBLTA4H | |
| SCHEMBL90572 | 0.60 | PDE10A (0.45) | SLC6A2SLC6A4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2910280 | 0.60 | PDE10A (0.45) | SLC6A2SLC6A4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2908444 | 0.60 | PDE10A (0.45) | SLC6A2SLC6A4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL24665898 | 0.59 | CYP1A2 (0.61) | ALDH1A1LMNAPOLBPGRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5883094-A | Benzimidazolone derivatives with central dopaminergic activity | PFIZER INC. (US) | 1999-03-16 | — | — | US | disclosed |