Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | CES1 | P23141 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL28690163 | 1.00 | MAPK1 (0.58) | MAPK1TDP1MAPTKMT2ACES1 | |
| SCHEMBL8657431 | 0.94 | MAPT (0.52) | MAPK1TDP1MAPTKMT2ACES1 | |
| Fluorobenzene SCHEMBL28684421 | 0.90 | HSD11B1 (0.49) | MAPK1TDP1MAPTKMT2ACES1 | |
| Anisole SCHEMBL28690179 | 0.85 | L3MBTL1 (0.54) | TDP1MAPTKMT2ACES1MEN1 | |
| SCHEMBL3629497 | 0.81 | ALDH1A1 (0.63) | MAPK1TDP1MAPTKMT2ACES1 | |
| SCHEMBL29087821 | 0.81 | POLB (0.49) | MAPK1TDP1MAPTKMT2ACES1 | |
| SCHEMBL571114 | 0.81 | TDP1 (0.58) | MAPK1TDP1MAPTKMT2ACES1 | |
| SCHEMBL10556922 | 0.80 | TDP1 (0.57) | MAPK1TDP1MAPTKMT2ACES1 | |
| SCHEMBL22313390 | 0.79 | CES1 (0.56) | MAPK1TDP1MAPTKMT2ACES1 | |
| SCHEMBL136826 | 0.79 | CES1 (0.56) | MAPK1TDP1MAPTKMT2ACES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1294699-B1 | MODULATORS OF TNF- ALPHA SIGNALLING | GENZYME CORP (US) | 2016-04-13 | — | — | EP | claimed |
| EP-1051413-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-04 | — | — | EP | claimed |
| EP-0548664-B1 | 2,3,3a-5,9b-hexahydro-1H-benzo(e)indole derivatives | HOFFMANN LA ROCHE (CH) | 1995-05-31 | — | — | EP | claimed |
| CN-114057623-B | N-naphthyl indole derivative and synthesis method thereof | 湖南第一师范学院 | 2023-07-21 | — | — | CN | disclosed |
| CN-114057623-A | N-naphthyl indole derivative and synthetic method thereof | 湖南第一师范学院 | 2022-02-18 | — | — | CN | disclosed |
| WO-2008018063-A2 | TETRAARYLPORPHINE DERIVATIVES AND USES THEREOF | KODESH S.A (LU) | 2008-02-14 | — | — | WO | disclosed |