Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 4/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | SORD | Q00796 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6714657 | 0.87 | HRH4 (0.55) | HRH4HTR1AHTR1BHTR1DSLC6A4 | |
| SCHEMBL6715832 | 0.83 | HTR1A (0.63) | HRH4HTR1AHTR1BHTR1DSLC6A4 | |
| SCHEMBL6719110 | 0.82 | DRD3 (0.59) | HRH4HTR1ADRD3 | |
| SCHEMBL7078939 | 0.80 | DRD3 (0.60) | HRH4HTR1AHTR7DRD3 | |
| Hydrochloric Acid SCHEMBL6714590 | 0.79 | DRD3 (0.59) | HRH4HTR1AHTR7DRD3 | |
| SCHEMBL6715989 | 0.77 | DRD2 (0.59) | HRH4HTR1AADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL6714596 | 0.77 | HRH4 (0.56) | HRH4HTR1AHTR1BHTR1DSLC6A4 | |
| SCHEMBL7560710 | 0.76 | HRH4 (0.58) | HRH4HTR1AHTR2CHTR7 | |
| SCHEMBL6711688 | 0.76 | HRH4 (0.52) | HRH4HTR1AHTR1BHTR1DSLC6A4 | |
| SCHEMBL6715613 | 0.76 | HTR1A (0.49) | HRH4HTR1AHTR1BHTR1DSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296954-A1 | BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | Abbott GmbH & Co. KG (DE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002002529-A1 | BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA | ABBOTT GMBH & CO. KG (DE) | 2002-01-10 | — | — | WO | disclosed |